| Name: |
| Andrzej Paszczynski |
| Title: |
| Associate Professor |
| Degree: |
| Ph.D., 1980, University of Marie Curie-Sklodowska |
| Phone: |
| (208) 885-6318 |
| Fax: |
| (208) 885-5741 |
| Email: |
| andrzej@uidaho.edu |
| Lab/Office Location: |
| Food Research Center, Room 103 |
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Computer generated models of pdtc copper and iron complexes.
In EBI laboratory, we isolated pdtc from Pseudomonas stutzeri, and determined its structures.
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| Research Interests: |
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Research involves the study of biodegradation (bioremediation) of organic compounds, including nitroaromatics (TNT, RDX, dinoseb),
chlorinated aromatic (pentachlorophenol) and aliphatic (carbon tetrachloride) compounds, azo compounds (azo dyes), and petroleum
hydrocarbons (diesel), by fungi and bacteria.
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Other interests include the reaction mechanism of peroxidases and ligninase, the biomimetic application of non-biological catalysts
in redox reactions, and the possibility of designing biodegradability into the structure of organic compounds, using azo dye isomers
and plastic polymers as model compounds. Research also involves studying the structures, and reaction mechanisms of the porphyrins
and heme proteins and small oranometalic complexes (siderophores).
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Theoretical research involves work with computer-generated models of enzymes (peroxidases) and small and large organometallic
molecules. Areas of interest include energy minimization, homology modeling, molecular orbital calculations, and 3D visualizations
using Insight II software from Accelrys Inc. and a Silicon Graphic computer.
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| Selected Publications: |
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Cortese, M. S., A. Paszczynski, T. A. Lewis, J. L. Sebat, V. Borek, and R. L. Crawford. 2002. Metal chelating properties of pyridine-2,6-bis(thiocarboxylic acid) produced by Pseudomonas spp. and the biological activities of the formed complexes. BioMetals. 15:103-120.
Qingyong, L., F. Cheng, Ch. M. Wai, A. Paszczynski, R. L. Crawford, B. Barnes, T. J. Anderson, R. Wells, G. Corti, L. Allenbach, D. P. Ervin, T. Assefi, and M. Mojarradi. 2002. Supercritical fluid extraction and high-performance liquid chromatography-diode array-electrochemical detection of signature redox compounds from sand and soil samples. Anal. Biochem. 301:225-234.
Newcombe, D., A. Paszczynski, W. Gajewska, M. Kroger, G. Feis, and R. L. Crawford. 2002. Production of small molecular weight catalysts and the mechanism of trinitrotoluene degradation by several Gloeophyllum species. Enzyme and Microbial Technology. 30:506-517. (Download pdf version)
Lewis, T.A., A. Paszczynski, S. W. Gordon-Wylie, S. Jeedigunta, C-H. Lee, and R. L. Crawford. 2001. Carbon tetrachloride dechlorination by the bacterial transition metal chelator pyridine-2,6-bis(thiocarboxylic acid). Environ. Sci. Technol. 35:552-559.
Crawford, R. L., A. Paszczynski, Q. Lang, I. F. Cheng, B. Barnes, T. J. Anderson, R. Wells, C. Wai, G. Corti, L. Allenbach, D. P. Erwin, J. Park, T. Assefi, and M. Mojarradi. 2001. Defining and measuring the chemical signatures of life. ICARUS. 154: 531-539.
Sebat, J. L., A. J. Paszczynski, M. S. Cortese, and R. L. Crawford. 2001. Antimicrobial Properties of Pyridine-2,6-dithiocarboxylic acid, a metal chelator produced by Pseudomonas spp. Appl. Environ, Microbiol. 67:3934-3942.
Stolworthy, J., A. Paszczynski, R. Korus, and R. L. Crawford. 2001. Metal binding by pyridine-2,6-bis(monothiocarboxylic acid), a biochelator produced by Pseudomonas stutzeri and Pseudomonas putida. Biodegradation. 12: 411-418.
Paszczynski, A. and R. L. Crawford. 2000. Recent advances in the use of fungi in environmental remediation and biotechnology, p. 379-422. In G. Stotzky, J.-M. Bollag (ed.), Soil Biochemistry, vol. 10. Marcel Dekker, New York.
Paszczynski, A., R. Crawford, D. Funk, and B. Goodell. 1999. De novo synthesis of 4,5-dimethoxycatechol and 2,5-dimethoxyhydroquinone by the brown rot fungus Gloeophyllum trabeum. Appl. Environ. Microbiol. 65:674-679.
Büyüksönmez, F., T. F. Hess, R. L. Crawford, A. Paszczynski, and R. J. Watts. 1999. Optimization of simultaneous chemical-biological mineralization of perchloroethylene. Appl. Environ. Microbiol. 65:2784-2788.
Lee, C.H., T.A. Lewis, A. Paszczynski, and R. L. Crawford. 1999. Identification of an extracellular agent of carbon tetrachloride dehalogenation from Pseudomonas stutzeri strain KC as pyridine-2,6-bis(thiocarboxylate). Biochem. Biophys. Res. Commun. 261:562-566.
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