| Name: |
| Patricia L. Hartzell |
| Title: |
| Associate Professor |
| Degree: |
| Ph.D. University of Illinois |
| Phone: |
| (208) 885-0572 |
| Fax: |
| (208) 885-6518 |
| Email: |
| hartzell@uidaho.edu |
| Lab/Office Location: |
| Life Science South, Room 156 |
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| Filaments of purified AglZ |
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| Research Interests: |
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Researchers in the Hartzell lab study the mechanisms by which the complex prokaryote, Myxococcus xanthus, coordinates two
independent motility systems during growth and development. Development is triggered when cells sense nutrient depletion and
commence to channel their movements toward central locations where they construct a multicellular fruiting body. Within 24 hours,
cells within the fruiting bodies differentiate into heat-resistant spores that remain quiescent until nutrients become available.
They have identified a Ras-like GTPase, MglA, that is essential for both motility systems and development. Genetic and biochemical
methods have identified proteins, including a tyrosine kinase and a coiled-coil protein that interact with MglA. They also are
studying the composition and cellular location of TolBQRA-like membrane complexes that are essential for one form of motility.
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| Selected Publications: |
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Youderian, Philip A, and Patricia L. Hartzell. 2005. Transposon insertions of magellan-4 that impair social gliding motility in Myxococcus xanthus. Genetics.
Yang, Ruifeng, Sarah Bartle, Rebecca Otto, Angela Stassinopoulos, Matthew Rogers, Lynda Plamann, and Patricia Hartzell. 2004. AglZ is a filament- forming coiled-coil protein required for gliding motility of Myxococcus xanthus. J. Bacteriol 186: 6168-6178.
Youderian, Philip A., Neal Burke, David J. White, and Patricia L. Hartzell. 2003. Identification of genes required for adventurous gliding motility in
Myxococcus xanthus with the transposable element mariner. Mol. Microbiol.49:555-570.
Thomason, Bobbie, Jason Link, Angela G. Stassinopoulos, Neal Burke, Lynda Plamann, and Patricia L. Hartzell. 2002. The GTPase, MglA, interacts with a tyrosine kinase to control type IV pili-mediated motility of Myxococcus
xanthus. Mol. Microbiol. 46:1399-1413.
Pagala, Vishwajeeth Reddy, Joohye Park, David W. Reed and Patricia L. Hartzell. 2002. Cellular localization of D-lactate dehydrogenase (Dld) and NADH oxidase (NoxA2) from Archaeoglobus fulgidus. Archaea 1:95-105.
Reed, David J., Jack Millstein, and Patricia L. Hartzell. 2001. H2O2 Forming NADH Oxidase with Diaphorase (Cytochrome) Activity from Archaeoglobus fulgidus. J. Bacteriol. 183:7007-7016.
White, David J., Robin Merod, Bobbie Thomasson, and Patricia L. Hartzell. 2001. GidA is a periplasmic FAD-binding protein involved in development of
Myxococcus xanthus. Molecular Microbiology.
42:503-518.
White, David J. and Patricia L. Hartzell. 2000. AglU, a protein required for gliding motility and spore maturation of Myxococcus xanthus, is related to WD-repeat proteins. Molecular Microbiology. 36:662-678.
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