|
|
 |
|
|
Regulation of the immune response to coronavirus infection in the lung |
Co-P.I. Tanya Miura
Abstract |
 |
| |
|
The focus of my research is the interaction between the alveolar epithelium and respiratory viral pathogens, specifically, the
role of the alveolar epithelial cells in initiating an immune response in the lung. The model I am studying is rat
coronavirus (RCoV) infection of primary cultures of rat alveolar type I and type II cells. Two strains of RCoV differ in
tissue tropism and disease severity in the rat, yet they have both been isolated from the lung during natural infection. I
have shown that both of these strains, Parker’s RCoV (RCoV-P) and sialodacryoadenitis virus (SDAV), infect primary rat type I
and type II cells. Furthermore, I have shown that RCoV infection of type I cells results in expression of CXC chemokines,
which is dependent partly on the cytokine IL-1. The primary function of CXC chemokines is to recruit and activate neutrophils.
Neutrophils are found early in tissues during coronavirus infection, however their role in viral clearance and/or
immunopathology during coronavirus infection is not known. My goals are to 1) Identify pathways for neutrophil recruitment to
the lung and activation upon RCoV infection; 2) Determine the viral and host cell components that are required to initiate the
IL-1 and CXC chemokine response; and 3) Examine the role of neutrophils in the outcome of disease, with regard to viral
clearance and immunopathology. These studies will define the early events in the immune response upon viral infection of the
lung and will lead to strategies for tipping the balance of the immune response toward viral clearance and away from
immune-mediated pathology.
|
| |
|
|
|
| researchers |
| Gustavo Arrizabalaga |
 |
| Potassium sensing by the obligate intracellular parasite Toxoplasma gondii |
|
| More info... |
| |
| Lee Fortunato |
 |
| Human cytomegalovirus interactions with cellular p53 |
|
| More info... |
| |
| Mark McGuire |
 |
| The impact of lipid metabolism on staphylococcal mastitis |
|
| More info... |
| |
| Bruce Miller |
 |
| Maintenance of hyphal polarity and its role in Aspergillus pathogenesis |
|
| More info... |
| |
| Tanya Miura |
|
| Regulation of the immune response to coronavirus infection in the lung |
|
| More info... |
| |
| pilot project researchers |
| Jill Johnson |
 |
| Role of Hsp90 in polarized cell morphogenesis in S. cerevisiae and C. albicans |
|
| More info... |
| |
| Carolyn Hovde Bohach |
 |
| The role of the large 'invasin-like' Y. pestis gene in pathogensis |
|
| More info... |
| |
| Scott Minnich |
 |
| The role of the large 'invasin-like' Y. pestis gene in pathogensis |
|
| More info... |
| |
|
